A toxicovenomic study was performed on the venom of the green mamba, 34 Dendroaspis angusticeps. Forty-two different proteins were identified in the venom of 35 D. angusticeps, in addition to the nucleoside adenosine. The most abundant proteins 36 belong to the three-finger toxin (3FTx) (69.2%) and the Kunitz-type proteinase inhibitor 37 (16.3%) families. Several sub-subfamilies of the 3FTxs were identified, such as Orphan 38 Group XI (Toxin F-VIII), acetylcholinesterase inhibitors (fasciculins), and aminergic 39 toxins (muscarinic toxins, synergistic-like toxins, and adrenergic toxins). Remarkably, 40 no ^-n^eurotoxins were identified. Proteins of the Kunitz-type proteinase inhibitor 41 family include dendrotoxins. Toxicological screening revealed a lack of lethal activity 42 in all RP-HPLC fractions, except one, at the doses tested. Thus, the overall toxicity 43 depends on the synergistic action of various types of proteins, such as dendrotoxins, 44 fasciculins, and probably other synergistically-acting toxins. Polyspecific antivenoms 45 manufactured in South Africa and India were effective in the neutralization of venom-46 induced lethality. These antivenoms also showed a pattern of broad immunorecognition 47 of the different HPLC fractions by ELISA and immunoprecipitated the crude venom by 48 gel immunodiffusion. The synergistic mechanism of toxicity constitutes a challenge for 49 the development of effective recombinant antibodies, as it requires the identification of 50 the most relevant synergistic toxins.