Antivenom is the most effective treatment modality for snake envenoming. However, they are specific and effective against only one or a few snake venoms. Production of antivenom against many snake species covering a wide geographic area of some countries or regions e.g., Asia and Africa, is not yet possible. This study aimed to use a simple procedure to pro-duce horse antiserum which could neutralize many or all medically important elapid (neu-rotoxic) snakes (cobras, kraits) of Asia. The venoms of 6 elapid species were obtained from 12 different regions/countries of Asia. Nine of these venoms were ultra-filtered to remove high molecular weight, non-toxic proteins to obtain the toxin fractions (TFs) for use as immunogen and thus enable inclusion of greater variety of elapid venoms. The 9 ‘toxin fractions’ together with the remaining 3 crude venoms were used to immunize 3 horses. The antisera of the horses obtained were shown to neutralize, in mice, the lethal effects of the venoms used in the immunization and 16 other Asian/African elapid venoms not used in the immunization. Thus, the simple strategy could broaden the neutralizing capacity of the resulting antiserum.