We note the response of Jackson et al. (2012) to our collective replies (Toxicon 60, 954–963 and 60, 964–966) to their paper entitled, “The structural and functional diversification of the Toxicofera reptile venom system”, Fry, B.G., Casewell, N.R., Wüster, W., Vidal, N., Young, B., Jackson, N.W.J. 2012; Toxicon 60, 434–448. Although their response contains numerous misinterpretations of our comments, as well as further speculation, we are only addressing a few select points that were germane to our reply to their criticisms of the terminology used in our book (Weinstein et al., 2011). Further opinionated debate on this subject can interminably clutter future issues of Toxicon with our respective interpretations without a mutually agreeable resolution. Therefore, our final comments are restricted only to the important issues, and this necessarily truncated response should not imply agreement with other comments made by Jackson et al. (2012), because as stated above, it is not desirable to perpetuate ongoing, lengthy debates without probable resolution