Histopathological and ultrastructural changes in liver tissues following intraperitoneal (i.p.) single LD50 of Naja  naja   snake venom   (0. 055μg/g) body weight   were studied.  Tissues were obtained for histological and ultrastructural studies at   3 h  and 24 h time intervals following injection of venom. Material and methods: A total of 18 adult male albino mice  were used; divided into three groups; each containing 6 rats: First group: as control.Second and third group:  treaded with   i.p.  single   LD50 of Naja naja   snake venom   (0. 055μg/g) body weight  ,  sacrificed after 3 and 24h  respectively.The liver of the control and treated mice were dissected out for histological and ultrastructural examinations .   Results: Histopathological and  ultra structural   degenerative effects in the form of vacuolar  degeneration,      hydropic degeneration ,   lymphocytic infiltration ,  Kupffer cells hyperplasia  ,  mitochondria were condensed darkly stained  in most of the hepatic cells,   lipid droplets were noticed in  venom treated mice  liver. Karyolysis and karyorrhexis were also seen. .  Conclusion: snake-envenoming causes several  disorders  such as intrahepatic hemorrhage , liver necrosis and hepatotoxicity.